Adaptive Platform Trials The Clinical Trial of the Future
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In the world of clinical trials, the past often doesn’t exist: You’re a clinician or a researcher, you know what’s working. But in a world where patient preferences are always changing, and drug efficacy is constantly getting refined, you need a platform that can adjust as you do. Advantages: 1. Adaptability: Your clinical trials should be as adaptable as your patients. By adapting quickly to changing situations, you can optimize efficiency and save costs. 2. Simplicity
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Adaptive Platform Trials (APTs) are the future of clinical trial design. Based on an excellent paper by David Feinberg (https://www.thelancet.com/journals/lanmed/article/PIIS2561-2966(20)32237-6/fulltext) on “Adaptive Clinical Trials: Inception, Design and Implementation”, I thought it would be worth sharing here how the APTs would look in a “Clinical
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In a fast-moving industry, there’s often pressure to complete all clinical trials within a fixed budget, timeline, and quality standards. While standard trials do not typically fail, they can be costly to execute. However, when it comes to the clinical development of new treatments or medications, adaptive platforms provide a more efficient, affordable, and customized way of testing new formulations. In this section, I’ll walk you through the adaptive platform concept and its impact on future clinical trial design, execution, and outcomes.
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Adaptive Platform Trials The Clinical Trial of the Future are an entirely new paradigm in drug development. It uses real-time patient data to constantly adapt trial designs to patients’ changing biology and treatments. A platform for these adaptive trials exists, yet it is still in its developmental stages. There are no approved clinical trials utilizing this type of trial strategy, yet. read here However, it is being developed for patients suffering from conditions such as cancer, diabetes, and heart disease. A pilot project was initiated in 20
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In Adaptive Platform Trials the Clinical Trial of the Future, the healthcare provider has the ability to use patient data to tailor therapies to a patient’s unique characteristics, allowing the clinician to provide the most effective treatment for each patient. Discover More This unique and revolutionary approach has the potential to save millions of lives in the next decade and beyond. This paper describes the key concepts of Adaptive Platform Trials, outlines the practical application of the technology, and provides case examples from healthcare providers using this approach. Section 1
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As the global pandemic continues, the world is grappling with the challenges that it presents. As many countries have introduced lockdowns to curb the spread of the virus, the medical community has to ramp up its efforts to test the drugs and vaccines for treatments and immunizations for the novel coronavirus. It is at that juncture where adaptive platform trials came into play. A platform trial is a way to optimize treatments by continuously testing them for their effectiveness, safety, and adverse reactions. With
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In an open trial, there are some limitations that should be mentioned: 1. The data from the trial cannot be trusted because no randomization was used, thus it might be impossible to compare the different treatment arms. However, this is the same problem for many randomized clinical trials. 2. The participants in the trial might be biased, for example those with comorbidities might receive different treatments or those with specific needs might be omitted. But this problem can be resolved through rigorous screening, selection criteria, and adequate informed consent.
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As a leading academic health system, Emory University School of Medicine, is constantly pushing forward in innovative clinical research strategies. Adaptive Platform Trials (APT) is one of the most recent and rapidly growing trends in clinical research in the US. We have been working to develop the Emory University APT program and were thrilled to participate in the initial APT clinical trials of a Phase III drug. Here’s how APT works. In APT trials, we test the drugs first in a “pre-